myrwdРеальная клиническая практика: данные и доказательстваReal-World Data & Evidence2782-3784Publishing House OKI10.37489/2782-3784-myrwd-064LWCLXMmyrwd-87Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫACTUAL REVIEWОбзор исследований реальной клинической практики применения капматиниба при раке лёгкого с мутацией МЕТReview of real-world studies on capmatinib use in MET-mutated lung cancerhttps://orcid.org/0000-0003-3031-4572КурылевА. А.KurylevA. A.

Курылев Алексей Александрович — к. м. н., доцент кафедры клинической фармакологии и доказательной медицины

Санкт-Петербург

Alexey A. Kurylev — Cand. Sci. (Med.), associate professor Department of Clinical Pharmacology and Evidence-Based Medicine

St. Petersburg

alexey-kurilev@yandex.ruhttps://orcid.org/0000-0002-1919-2909КолбинА. С.KolbinA. S.

Колбин Алексей Сергеевич — д. м. н., профессор, зав. кафедрой клинической фармакологии и доказательной медицины; профессор кафедры фармакологии медицинского факультета

Санкт-Петербург

Alexey S. Kolbin — Dr. Sci. (Med.), Professor, Head. Department of Clinical Pharmacology and Evidence-Based Medicine; Professor of the Department of Pharmacology, Faculty of Medicine

St. Petersburg

https://orcid.org/0009-0002-6681-232XСвечкареваИ. Р.SvechkarevaI. R.

Свечкарева Изабелла Размиковна — ординатор кафедры клинической фармакологи и доказательной медицины

Санкт-Петербург

Izabella R. Svechkareva — resident of the department of Clinical Pharmacology and Evidence-Based Medicine

St. Petersburg

Bellaliza@yandex.ruФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени И. П. Павлова»РоссияFirst St. Petersburg State Medical University named after I. P. PavlovRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени И. П. Павлова»; ФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияFirst St. Petersburg State Medical University named after I. P. Pavlov; St. Petersburg State University,Russian Federation20252504202551312Copyright © Курылев А.А., Колбин А.С., Свечкарева И.Р., 20252025Курылев А.А., Колбин А.С., Свечкарева И.Р.Kurylev A.A., Kolbin A.S., Svechkareva I.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.myrwd.ru/jour/article/view/87

Рак лёгкого занимает лидирующие позиции в структуре смертности от злокачественных новообразований, так в 2022 году смертность от рака лёгкого составила 31,66 на 100 тыс. населения, в 2022 г. 44 981 больных взято на учёт с впервые в жизни установленным диагнозом рак лёгкого, одногодичная летальность составляет 44,8 %. Одним из генов, участвующим в развитии опухолевых клеток рака лёгкого является ген МЕТ, в котором обнаружено несколько различных мутаций, однако именно делеция 14 экзона является наиболее часто встречающейся, эта мутация встречается в 3–4 % случаев немелкоклеточного рака лёгкого (НМЛР) и является независимым фактором плохого прогноза и ассоциирована с короткой общей выживаемостью. Лекарственный препарат капматиниб был впервые зарегистрирован в 2020 году именно для лечения НМРЛ при наличии делеции 14 экзона в гене МЕТ. Целью исследования является систематический обзор исследований реальной клинической практики капматиниба при НМРЛ.

Lung cancer occupies a leading position in the structure of mortality from malignant neoplasms, so in 2022, mortality from lung cancer was 31.66 per 100,000 population, in 2022, 44,981 patients were registered with a diagnosis of lung cancer for the first time in their life, the one-year mortality rate is 44.8 %. One of the genes involved in the development of lung cancer tumor cells is the MET gene, in which several different mutations have been found, but the deletion of exon 14 is the most common. This mutation occurs in 3–4 % of cases of non-small-cell lung cancer (NSCLC), is an independent factor in poor prognosis, and is associated with short overall survival. The drug capmatinib was first registered in 2020 specifically for treating NSCLC in the presence of a deletion of exon 14 in the MET gene. This study systematically reviewed the real-world clinical practice studies of capmatinib in NSCLC.

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The authors declare that there are no conflicts of interest present.