myrwdРеальная клиническая практика: данные и доказательстваReal-World Data & Evidence2782-3784Publishing House OKI10.37489/2782-3784-myrwd-068VZWAZDmyrwd-91Research ArticleИССЛЕДОВАНИЯ ПОТРЕБЛЕНИЯ ЛЕКАРСТВDRUG UTILIZATION RESEARCHФармакоэпидемиология антидепрессантов в Российской ФедерацииPharmacoepidemiology of antidepressants in the Russian Federationhttps://orcid.org/0000-0001-7704-9900ГомонЮ. М.GomonYu. M.

Гомон Юлия Михайловна –– д. м. н., профессор кафедры клинической фармакологии и доказательной медицины

Санкт-Петербург

Yulia M. Gomon — Dr. Sci. (Med.), professor of the department of Clinical Pharmacology and Evidence-Based Medicine

gomonmd@yandex.ruhttps://orcid.org/0000-0002-1919-2909КолбинА. С.KolbinA. S.

Колбин Алексей Сергеевич –– д. м. н., профессор, зав. кафедрой клинической фармакологии и доказательной медицины; профессор кафедры фармакологии медицинского факультета

Санкт-Петербург

Alexey S. Kolbin –– Dr. Sci. (Med.), Professor, Head. Department of Clinical Pharmacology and Evidence-Based Medicine; Professor of the Department of Pharmacology, Faculty of Medicine

St. Petersburg

https://orcid.org/0009-0004-5852-1519ЛавроваВ. А.LavrovaV. A.

Лаврова Виктория Анатольевна –– к. м. н., ассистент кафедры психиатрии и наркологии

Санкт-Петербург

Victoria A. Lavrova –– Cand. Sci. (Med.), Assistant Professor at the Department of Psychiatry and Narcology

St. Petersburg

valavrova@bk.ruhttps://orcid.org/0000-0001-5618-4206НезнановН. Г.NeznanovN. G.

Незнанов Николай Григорьевич –– д. м. н., профессор, зав. кафедрой психиатрии и наркологии; директор

Санкт-Петербург

Nikolay G. Neznanov –– Dr. Sci. (Med.), Professor, Head of the Department of Psychiatry and Narcology; Director

St. Petersburg

Neznanov.spbgmu@gmail.comФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени И. П. Павлова»РоссияFirst St. Petersburg State Medical University named after I. P. PavlovRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени И. П. Павлова»; ФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияFirst St. Petersburg State Medical University named after I. P. Pavlov; St. Petersburg State UniversityRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени И. П. Павлова»; ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В. М. Бехтерева»РоссияFirst St. Petersburg State Medical University named after I. P. Pavlov; V. M. Bekhterev National Research Medical Center of Psychiatry and NeurologyRussian Federation202525042025514958Copyright © Гомон Ю.М., Колбин А.С., Лаврова В.А., Незнанов Н.Г., 20252025Гомон Ю.М., Колбин А.С., Лаврова В.А., Незнанов Н.Г.Gomon Y.M., Kolbin A.S., Lavrova V.A., Neznanov N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.myrwd.ru/jour/article/view/91Цель

Цель. Оценка динамики объёмов и структуры потребления антидепрессантов в Российской Федерации (РФ).

Материалы и методы

Материалы и методы. Из базы данных IQVIA выгружены данные о продажах лекарственных средств, относящихся к классу АТХ N06A (антидепрессанты), согласно действующим российским клиническим рекомендациям применяемых у пациентов с невротическими, связанными со стрессом и соматоформными расстройствами (код МКБ F40‑F48) в период 2019–2024 гг. Рассчитано ориентировочное количество пациентов, получивших годичный курс одного из рассматриваемых международных непатентованных наименований, а также количество установленных дневных доз (DDD) на 1000 жителей в день в каждый из годов наблюдения.

Результаты

Результаты. В период 2019–2024 гг. в РФ отмечен более чем двукратный рост продаж антидепрессантов: в 2019 г. продано 200 млн, в то время как в 2024 г. — порядка 500 млн DDD, что соответствует 3,8 DDD/1000 жителей в день в 2019 г. и 9,4 DDD/1000 жителей в день в 2024 г. Расчётное количество пациентов, получивших годичный курс антидепрессантов, увеличилось с 570 тыс. в 2019 г. до 1,38 млн человек в 2024 г. Преимущественный канал продаж на всём протяжении наблюдения — розничные продажи, которые составляли от 84 % в 2019 г. до 94 % в 2024 г. всего объёма продаж в каждом из годов наблюдения. Основную долю продаж (до 75 %) составляют селективные ингибиторы обратного захвата серотонина (прежде всего сертралин и эсциталопрам). Объёмы региональных продаж коррелировали с численностью населения регионов.

Выводы

Выводы. Расширение практики применения антидепрессантов в РФ требует тщательного сбора данных о безопасности как в рамках анализа национальной базы данных «Фармаконадзор», так и в рамках проведения исследований реальной клинической практики.

Objective

Objective. To assess the volume and structure dynamics of antidepressant consumption in the Russian Federation (RF).

Materials and methods

Materials and methods. Data on the sales of medicines belonging to the ATX class N06A (antidepressants) were downloaded from the IQVIA database in the period 2019–2024. Selected those mentioned in the current Russian clinical guidelines for use in patients with neurotic, stress-related and somatoform disorders (ICD code F40‑F48). The estimated number of patients who received a one-year course of antidepressants, as well as the number of DDDs/1000 inhabitants per day in each of the follow-up years, was calculated.

Results

Results. In the period 2019–2024, sales of antidepressants more than doubled in the RF: 200 million were sold in 2019, while about 500 million DDDs in 2024, which corresponds to 3.8 in 2019 and 9.4 DDDs/1000 inhabitants per day in 2024. The estimated number of patients who received a one-year course of antidepressants increased from 570,000 in 2019 to 1.38 million in 2024. The predominant sales channel throughout the observation period was retail sales, which accounted for 84 % in 2019 to 94 % in 2024 of the total sales in each of the observation years. SSRIs (primarily sertraline and escitalopram) accounted for most sales (up to 75 %) throughout the follow-up. Regional sales correlated with the size of the region’s population.

Conclusions

Conclusions. The expansion of the practice of using antidepressants in the RF requires careful collection of safety data both as part of the analysis of the national Pharmacovigilance database and as part of real clinical practice research.

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The authors declare that there are no conflicts of interest present.