Retracted article: Khatkov I.E., Andreyashkina I.I., Trotsenko I.D., Matveeva O.N., Reznikov V.A. The ICEDORA study: clinical and demographic characteristics and treatment regimens of patients with HR+ HER2- locally advanced or metastatic breast cancer receiving CDK4/6 inhibitors in real clinical practice. Real-World Data & Evidence. 2025;5(2):83-100. (In Russ.) https://doi.org/10.37489/2782-3784-myrwd-076. EDN: EFAKGL.
An article can be withdrawn (retracted) from the journal “Real-World Data & Evidence” upon an official request to the editorial board of the journal from the authors of the article stating that:
“After a second review, a decision was made to retract the article due to identified methodological problems that cast doubt on the correctness of some of the presented results and their interpretation.
The main reason is the data that provoke a direct comparison of outcomes between incomparable treatment groups without proper statistical adjustment, which is not acceptable within the framework of the study design and contradicts the rationale for the key additional objective of the study.
An incorrect survival analysis was performed without taking into account the effect of insufficient statistical power due to the sample size. This limits the possibilities for interpreting the results and makes statements about the absence of significant differences in the comparative survival analysis statistically unfounded. Such conclusions are permissible only if the power of the study allows for reliable confirmation or refutation of the hypothesis about the absence of differences.
Calculating overall survival from diagnosis rather than from the start of CDK4/6 inhibitor therapy does not allow us to assess the direct contribution of the drugs being studied to survival, since this indicator is greatly influenced by the patient's medical history and previous treatment.
Figure 3 shows incorrect graphs that do not correspond to the text and may mislead the reader." (letter date September 10, 2025).
Reason for retracting the article:
After re-checking the article, a decision was made to retract the article. The retraction of the article was due to the identification of methodological problems that cast doubt on the correctness of some of the presented results and their interpretation.
Minutes of the meeting of the Publication Ethics Committee of the journal "Real Clinical Practice: Data and Evidence" No. 2 dated 12.09.2025.
The editorial board would like to offer its sincere apologies for any inconvenience caused by the retraction of the article.
Minutes of the meeting of the Publication Ethics Committee of the journal "Real-World Data & Evidence" No. 2 dated 12.09.2025.
The Editorial Board would like to extend their sincere apologies for any inconvenience this retraction may have caused.
