Impact of third molars on quality of life in modern society
https://doi.org/10.37489/2782-3784-myrwd-082
Abstract
Actuality. Third molar problems have a multifactorial negative impact on patients’ quality of life (QoL), affecting the medical, psychological, social, and economic aspects of life. A comprehensive assessment of this impact is a pressing task for optimizing dental care and improving patients’ quality of life.
Objective. This study conducted a systematic analysis of modern data on the impact of third molars on various aspects of QoL by assessing the influence of medical, psychological, social, and economic factors.
Materials and methods. A systematic review of the scientific literature was conducted from 2020 to 2025 using the PubMed, Scopus, Web of Science, and Google Scholar databases. The inclusion criteria included publications published after 2020 containing statistical data on the impact of third molars on patients’ lives. Content analysis was used to systematize the data using validated QOL assessment tools, including OHIP-5, PSQI, AIS, and ESS.
Results. It was found that 52 % of patients with third molar problems suffer from sleep disorders, with an insomnia score of 5.56±3.23 points on the AIS scale. The risk of developing caries of adjacent teeth increases by 1.39 times and root resorption by 6.51 times. The overall QoL score of patients with impacted molars is 0–14 points versus 0–11 in the control group (p<0.05). The economic analysis showed that conservative management is the costliest approach compared with prophylactic extraction. The strategy of preserving asymptomatic third molars provide cost savings for national health care systems.
Conclusions. Third molars have a significant negative impact on patients’ QoL through sleep disorders, dental complications, and psychosocial dysfunction. The constructed model of multifactorial impact allows predicting the need for various types of dental care and optimizing the health care system’s economic costs for third molar pathology treatment.
About the Author
A. A. MkrtichyanRussian Federation
Artem A. Mkrtichyan –– postgraduate student, Department of Pharmacology and Evidence-Based Medicine
Saint Petersburg
Competing Interests:
Authors declare no conflict of interest requiring disclosure in this article
References
1. Babakhin E. B., Bondaryuk A. V. Features and developmental anomalies of third molars. Young scientist. 2023;2(65):104-114. (In Russ). URL: https://moluch.ru/young/archive/65/3340/
2. WHO. International Statistical Classification of Diseases and Related Health Problems 11th Revision (ICD-11). Geneva: WHO; 2022.
3. Pinto AC, Francisco H, Marques D, et al. World-wide Prevalence and Demographic Predictors of Impacted Third Molars-Systematic Review with Meta-Analysis. J Clin Med. 2024 Dec 11;13(24):7533. doi: 10.3390/jcm13247533.
4. Ali Tergam Abdulamir Ali, Pokhodenko-Chudakova I. O. Retained dystopic third molars of the lower jaw. Current state of the issue. Modern dentistry. 2022;1(86):47-49. (In Russ).
5. Kan S., Ehrlich P. R. The bite of evolution. Where do modern humans get malocclusion, crooked teeth and other jaw deformities. Moscow: Eksmo; 2021. 173 p. (In Russ).
6. Buvinic S, Balanta-Melo J, Kupczik K, et al. Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions. Front Endocrinol (Lausanne). 2021 Mar 1;11:606947. doi: 10.3389/fendo.2020.606947.
7. Gebeyehu T, Abaynew Y. Prevalence and patterns of third molar impaction among Ethiopians in Addis Ababa: a retrospective pilot study. Sci Rep. 2024 Apr 18;14(1):8952. doi: 10.1038/s41598-024-59821-x.
8. Vagner VD, Korshunov AS, Kuryatnikov KN, et al. General ideas about the stages, classifications, pathological conditions during the lower third molars eruption in humans. Literature review. Part 2. Stomatology. 2023;102(5):76-80. (In Russ.)] doi: 10.17116/stomat202310205176.
9. Poszytek D, Górski B. Relationship between the Status of Third Molars and the Occurrence of Dental and Periodontal Lesions in Adjacent Second Molars in the Polish Population: A Radiological Retrospective Observational Study. J Clin Med. 2023 Dec 19;13(1):20. doi: 10.3390/jcm13010020.
10. Gürses G, Akçakaya A, Aktı A, Aydin O. The effect of impacted third molars on second molar external root resorption, a cross-sectional cone beam computed tomography study. Med Oral Patol Oral Cir Bucal. 2023 Nov 1;28(6):e504-e511. doi: 10.4317/medoral.25860.
11. Lyros I, Vasoglou G, Lykogeorgos T, et al. The Effect of Third Molars on the Mandibular Anterior Crowding Relapse-A Systematic Review. Dent J (Basel). 2023 May 9;11(5):131. doi: 10.3390/dj11050131.
12. Ahmed HA, López-López J, Egido-Moreno S, et al. Mandibular Third Molar Impaction and Bone Change Distal to the Second Molar: A Panoramic Radiographic Study. J Clin Med. 2024 Feb 4;13(3):906. doi: 10.3390/jcm13030906.
13. Li Z, Fan B, Wu T, et al. Special diffusion pathway of pericoronitis of the third molar: A case report and literature review. Int J Surg Case Rep. 2024;119:109709. doi: 10.1016/j.ijscr.2024.109709.
14. Djohan FFS, Yusma VH, Nasution RN. Management of Chronic Pericoronitis of Lower Third Molars with Periodontal Operculectomy Surgical Approach (Case Report). Jurnal Eduhealt. 2022;13(01):27-38.
15. Kwon G, Serra M. Pericoronitis. In: StatPearls Internet Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576411/
16. Mksoud M, Ittermann T, Daboul A, et al. Are third molars associated with orofacial pain? Findings from the SHIP study. Community Dent Oral Epidemiol. 2020;48(5):364-370. doi: 10.1111/cdoe.12540.
17. Bukhari OM, Alhassani SL, Alkhudhayri SL et al. The Influence of Impacted Mandibular Third Molar in Health-related Quality of Life. Open Dent J. 2025;19:e18742106375371.
18. Global Burden of Disease 2015 study. Open Dent J. 2025;19:e18742106375371.
19. Apessos I, Lillis T, Voulgaris A, et al. Effect of Third Molar Surgery on Sleep Health Parameters of Young Adults: An Observational Study. Medicina (Kaunas). 2024 May 24;60(6):858. doi: 10.3390/medicina60060858.
20. Hanna K, Sambrook P, Armfield JM, Brennan DS. Exploring and modelling impacts of third molar experience on quality of life: a real-time qualitative study using Twitter. Int Dent J. 2020;67(5):272-280. doi: 10.1111/idj.12298.
21. G P, Ramalingam K, Ramani P. Unveiling the Unspoken: Exploring Oral Manifestations of Psychological Disorders. Cureus. 2024 Jan 25;16(1):e52967. doi: 10.7759/cureus.52967.
22. Alfadil L, Almajed E. Prevalence of impacted third molars and the reason for extraction in Saudi Arabia. Saudi Dent J. 2020 Jul;32(5):262-268. doi: 10.1016/j.sdentj.2020.01.002.
23. Alhajj MN, Halboub E, Khalifa N, et al. Translation and validation of the Arabic version of the 5-item Oral health impact profile: OHIP5-Ar. Health Qual Life Outcomes. 2018 Nov 20;16(1):218. doi: 10.1186/s12955-018-1046-0.
24. Chidley E, Burns-Nader S. Exploring young adults' fears related to healthcare and dental procedures. J Family Med Prim Care. 2024 May;13(5):1830-1836. doi: 10.4103/jfmpc.jfmpc_961_23.
25. Kurki P, Korhonen M, Honkalampi K, Suominen AL. Patients' multifaceted views of dental fear in a diagnostic interview. Acta Odontol Scand. 2021 Apr;79(3):194-204. doi: 10.1080/00016357.2020.1817545.
26. Murad MH, Ingle NA, Assery MK. Evaluating factors associated with fear and anxiety to dental treatment-A systematic review. J Family Med Prim Care. 2020 Sep 30;9(9):4530-4535. doi: 10.4103/jfmpc.jfmpc_607_20.
27. Chowdhury AR, Graham PL, Schofield D, et al. Productivity outcomes from chronic pain management interventions in the working age population; a systematic review. Pain. 2024 Jun 1;165(6):1233-1246. doi: 10.1097/j.pain.0000000000003149.
28. Koumaras GM. What costs are associated with the management of third molars? J Oral Maxillofac Surg. 2012 Sep;70(9 Suppl 1):S8-10. doi: 10.1016/j.joms.2012.04.023.
29. Edwards MJ, Brickley MR, Goodey RD, Shepherd JP. The cost, effectiveness and cost effectiveness of removal and retention of asymptomatic, disease free third molars. Br Dent J. 1999 Oct 9;187(7):380-4. doi: 10.1038/sj.bdj.4800285.
30. Anjrini AA, Kruger E, Tennant M. Cost effectiveness modelling of a 'watchful monitoring strategy' for impacted third molars vs prophylactic removal under GA: an Australian perspective. Br Dent J. 2015 Jul 10;219(1):19-23. doi: 10.1038/sj.bdj.2015.529.
31. Northridge ME, Kumar A, Kaur R. Disparities in Access to Oral Health Care. Annu Rev Public Health. 2020 Apr 2;41:513-535. doi: 10.1146/annurev-publhealth-040119-094318.
Review
For citations:
Mkrtichyan A.A. Impact of third molars on quality of life in modern society. Real-World Data & Evidence. 2025;5(3):47-55. (In Russ.) https://doi.org/10.37489/2782-3784-myrwd-082






















